Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 128)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0297078	0.1087056	0.7873024
Weighted median	23	-0.0419651	0.0653913	0.5210338
Inverse variance weighted	23	-0.0440007	0.0415322	0.2894022
Simple mode	23	-0.1935607	0.1424193	0.1878885
Weighted mode	23	-0.2341198	0.1528462	0.1398425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.90654	21	0.2512344
Inverse variance weighted	24.93075	22	0.3003981

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008777	0.0061447	0.887774

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8