Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1279)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0237159	0.1035257	0.8210213
Weighted median	23	0.0343628	0.0595150	0.5636822
Inverse variance weighted	23	-0.0318262	0.0395401	0.4208732
Simple mode	23	0.0737993	0.1036650	0.4840072
Weighted mode	23	0.0680361	0.0752887	0.3759604

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.58810	21	0.3663267
Inverse variance weighted	22.59589	22	0.4248399

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004981	0.0058518	0.9329794

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007048	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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