Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1278)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0080985	0.0998204	0.9361060
Weighted median	23	0.0403677	0.0551161	0.4639173
Inverse variance weighted	23	0.0423605	0.0390155	0.2775962
Simple mode	23	0.1315160	0.1013872	0.2080132
Weighted mode	23	0.0316993	0.0645366	0.6281613

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.17471	21	0.6379230
Inverse variance weighted	18.47631	22	0.6774039

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030987	0.0056424	0.588671

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005956	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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