Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1277)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0956752	0.0998201	0.3487289
Weighted median	23	-0.0070862	0.0567327	0.9005989
Inverse variance weighted	23	-0.0175794	0.0390156	0.6522972
Simple mode	23	0.0018430	0.0942000	0.9845666
Weighted mode	23	-0.0212923	0.0658280	0.7494058

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.94341	21	0.5887706
Inverse variance weighted	20.46281	22	0.5541140

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069549	0.0056423	0.2313316

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006262	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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