Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1276)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0208425	0.1007964	0.8381744
Weighted median	23	-0.0624990	0.0558920	0.2634771
Inverse variance weighted	23	-0.0667053	0.0390154	0.0873181
Simple mode	23	-0.1491814	0.1029871	0.1615689
Weighted mode	23	-0.0752591	0.0669204	0.2728766

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.41277	21	0.4339970
Inverse variance weighted	21.66193	22	0.4802155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028164	0.0056975	0.6262066

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000745	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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