Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1275)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0713116	0.1089632	0.5199222
Weighted median	23	0.0638162	0.0605157	0.2916361
Inverse variance weighted	23	0.0698573	0.0416101	0.0931801
Simple mode	23	-0.0542003	0.1023741	0.6018071
Weighted mode	23	0.0507444	0.0746037	0.5034821

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.02353	21	0.2461463
Inverse variance weighted	25.02378	22	0.2959388

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-8.93e-05	0.0061591	0.9885678

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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