Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1274)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0194615	0.0999104	0.8474297
Weighted median	23	-0.0085549	0.0580926	0.8829237
Inverse variance weighted	23	-0.0271182	0.0390155	0.4870168
Simple mode	23	-0.1138630	0.1046726	0.2884570
Weighted mode	23	-0.0463951	0.0731678	0.5325592

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.03805	21	0.4566226
Inverse variance weighted	21.04499	22	0.5179589

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004702	0.0056474	0.9344348

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006524	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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