Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1273)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0960266	0.1104620	0.3945007
Weighted median	23	0.0545081	0.0530822	0.3044849
Inverse variance weighted	23	-0.0178100	0.0434229	0.6816942
Simple mode	23	0.0299292	0.0988247	0.7648482
Weighted mode	23	0.0793140	0.0675423	0.2528357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.71622	21	0.2174766
Inverse variance weighted	27.25128	22	0.2018376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069907	0.0062438	0.2755211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008321	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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