Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1272)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0652854	0.0998203	0.5201915
Weighted median	23	-0.0364708	0.0560094	0.5149468
Inverse variance weighted	23	-0.0387528	0.0390156	0.3205819
Simple mode	23	0.0131038	0.0919640	0.8879913
Weighted mode	23	-0.0214172	0.0712447	0.7665306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.21285	21	0.9336924
Inverse variance weighted	12.29624	22	0.9509555

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016294	0.0056423	0.7755839

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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