Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1271)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1134855	0.0998208	0.2683904
Weighted median	23	-0.0726231	0.0535796	0.1752821
Inverse variance weighted	23	-0.0385756	0.0390158	0.3228010
Simple mode	23	-0.0822262	0.0857668	0.3481192
Weighted mode	23	-0.0822262	0.0616292	0.1957825

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.64846	21	0.7321830
Inverse variance weighted	17.31317	22	0.7458454

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046002	0.0056423	0.4240515

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005543	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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