Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1270)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1438002	0.0998209	0.1644470
Weighted median	23	0.0073472	0.0522321	0.8881351
Inverse variance weighted	23	0.0570497	0.0390159	0.1436823
Simple mode	23	0.0177849	0.0809441	0.8281163
Weighted mode	23	-0.0022472	0.0599005	0.9704119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.14910	21	0.9598039
Inverse variance weighted	15.92769	22	0.8194585

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0123341	0.0056423	0.0402826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005474	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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