Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 127)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0690710	0.1052185	0.5186619
Weighted median	23	0.0252235	0.0640667	0.6937976
Inverse variance weighted	23	-0.0271518	0.0411132	0.5089872
Simple mode	23	0.0098045	0.1292231	0.9402060
Weighted mode	23	0.0556473	0.0841549	0.5153195

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.33278	21	0.3264952
Inverse variance weighted	24.42955	22	0.3251228

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005909	0.0059475	0.3317586

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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