Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1269)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0097232	0.0998204	0.9233272
Weighted median	23	-0.0628388	0.0570330	0.2705499
Inverse variance weighted	23	-0.0382855	0.0390153	0.3264475
Simple mode	23	0.0294499	0.0961566	0.7622789
Weighted mode	23	-0.0501771	0.0738966	0.5042080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.96162	21	0.5876022
Inverse variance weighted	19.05826	22	0.6417282

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001754	0.0056424	0.758967

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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