Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1268)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1000726	0.1166451	0.4006208
Weighted median	23	0.1654229	0.0572202	0.0038403
Inverse variance weighted	23	0.1470802	0.0447463	0.0010127
Simple mode	23	0.1554672	0.0928454	0.1081962
Weighted mode	23	0.1554672	0.0657167	0.0272255

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.67701	21	0.1219744
Inverse variance weighted	28.93877	22	0.1466172

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028867	0.0065934	0.665983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013075	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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