Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1267)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0592577	0.1129198	0.6052346
Weighted median	23	-0.0155426	0.0598705	0.7951690
Inverse variance weighted	23	0.0134123	0.0436197	0.7584768
Simple mode	23	-0.0010570	0.0995691	0.9916258
Weighted mode	23	-0.0078616	0.0709539	0.9127800

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.87361	21	0.1750761
Inverse variance weighted	27.49917	22	0.1928778

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044627	0.0063828	0.4921167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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