Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1266)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0649666	0.1018092	0.5302928
Weighted median	23	0.0289881	0.0530178	0.5845419
Inverse variance weighted	23	0.0155645	0.0391344	0.6908380
Simple mode	23	0.0774640	0.0856359	0.3754910
Weighted mode	23	0.0233556	0.0607775	0.7044595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.84499	21	0.4084894
Inverse variance weighted	22.13409	22	0.4519099

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030338	0.0057547	0.603595

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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