Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1265)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1238844	0.0998204	0.2282642
Weighted median	23	0.0155696	0.0540486	0.7732952
Inverse variance weighted	23	0.0384773	0.0403726	0.3405623
Simple mode	23	0.0240405	0.0826381	0.7738430
Weighted mode	23	0.0035497	0.0595793	0.9530287

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.43428	21	0.4939223
Inverse variance weighted	23.55696	22	0.3708734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099706	0.0056423	0.0917408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007432	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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