Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1264)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1025785	0.0998202	0.3158147
Weighted median	23	-0.0139488	0.0539224	0.7958804
Inverse variance weighted	23	-0.0757631	0.0390157	0.0521540
Simple mode	23	0.0054254	0.0947198	0.9548403
Weighted mode	23	-0.0024385	0.0673694	0.9714525

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.79976	21	0.8780459
Inverse variance weighted	17.56738	22	0.7313081

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109519	0.0056423	0.0657945

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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