Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1263)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0024696	0.0998196	0.9804950
Weighted median	23	-0.0989720	0.0585309	0.0908487
Inverse variance weighted	23	-0.0524817	0.0390153	0.1785746
Simple mode	23	-0.1097292	0.1121562	0.3385329
Weighted mode	23	-0.1375197	0.0930509	0.1536095

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.77673	21	0.6630865
Inverse variance weighted	18.07302	22	0.7016505

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030713	0.0056423	0.5919509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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