Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1262)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1256003	0.0998199	0.2221051
Weighted median	23	-0.0541264	0.0546238	0.3217368
Inverse variance weighted	23	-0.0261926	0.0390155	0.5020048
Simple mode	23	0.0303243	0.1066358	0.7787845
Weighted mode	23	-0.0767003	0.0652387	0.2522863

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.80843	21	0.5974275
Inverse variance weighted	19.97902	22	0.5843519

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061046	0.0056423	0.2915481

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006191	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8