Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1261)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0441901	0.1118580	0.6967864
Weighted median	23	0.0297039	0.0537314	0.5803857
Inverse variance weighted	23	0.0123501	0.0428126	0.7729874
Simple mode	23	0.1193947	0.0883463	0.1902890
Weighted mode	23	0.0187628	0.0612930	0.7623939

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.37024	21	0.1926820
Inverse variance weighted	26.49033	22	0.2312259

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019553	0.0063227	0.7601816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008057	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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