Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1260)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0538065	0.0998201	0.5955322
Weighted median	23	-0.0165931	0.0569434	0.7707479
Inverse variance weighted	23	-0.0454525	0.0390157	0.2440274
Simple mode	23	0.0213277	0.1004500	0.8338115
Weighted mode	23	-0.0139525	0.0622434	0.8247008

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.89883	21	0.5916299
Inverse variance weighted	18.90710	22	0.6510579

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000513	0.0056423	0.9284153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006141	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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