Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 126)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1265949	0.1154653	0.2853227
Weighted median	23	-0.0118910	0.0568093	0.8342033
Inverse variance weighted	23	-0.0266551	0.0450117	0.5537283
Simple mode	23	0.0358835	0.0864366	0.6820585
Weighted mode	23	-0.0288162	0.0589745	0.6299458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.09843	21	0.1373819
Inverse variance weighted	29.28156	22	0.1369962

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061373	0.0065266	0.3577332

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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