Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1259)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0255485	0.1142284	0.8251821
Weighted median	23	0.0207494	0.0591165	0.7255950
Inverse variance weighted	23	0.0121439	0.0436375	0.7807890
Simple mode	23	-0.0236926	0.1069822	0.8267743
Weighted mode	23	0.0126972	0.0709263	0.8595604

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.50026	21	0.1549017
Inverse variance weighted	27.52155	22	0.1920839

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008232	0.0064568	0.899765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008369	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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