Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1258)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1120968	0.0998207	0.2741204
Weighted median	23	-0.0357582	0.0557972	0.5216143
Inverse variance weighted	23	-0.0562152	0.0390156	0.1496305
Simple mode	23	-0.0308099	0.0935187	0.7449301
Weighted mode	23	-0.0247089	0.0625809	0.6967691

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.38205	21	0.6247154
Inverse variance weighted	18.75196	22	0.6605910

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034317	0.0056423	0.5495759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006311	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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