Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1257)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0878722	0.0998203	0.3886579
Weighted median	23	0.0214160	0.0585011	0.7143060
Inverse variance weighted	23	0.0364674	0.0390156	0.3499489
Simple mode	23	0.1015931	0.1051145	0.3442996
Weighted mode	23	-0.0092998	0.0780246	0.9062064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.43285	21	0.8502986
Inverse variance weighted	14.74587	22	0.8729113

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031568	0.0056423	0.5817532

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004733	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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