Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1256)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1699724	0.0998195	0.1033631
Weighted median	23	-0.0009408	0.0575210	0.9869504
Inverse variance weighted	23	-0.0191134	0.0399642	0.6324638
Simple mode	23	0.0197324	0.1001256	0.8455774
Weighted mode	23	0.0028805	0.0746020	0.9695483

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.38745	21	0.4968527
Inverse variance weighted	23.08338	22	0.3970340

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092643	0.0056423	0.1154961

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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