Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1255)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1126717	0.0998199	0.2717338
Weighted median	23	0.0374946	0.0541796	0.4889109
Inverse variance weighted	23	0.0627291	0.0390156	0.1078800
Simple mode	23	0.0314969	0.0868812	0.7204163
Weighted mode	23	0.0280199	0.0640943	0.6662511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.46887	21	0.7427558
Inverse variance weighted	16.76434	22	0.7762309

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003067	0.0056423	0.5924634

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005863	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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