Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1254)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0296925	0.0998210	0.7690401
Weighted median	23	0.0127470	0.0555527	0.8185132
Inverse variance weighted	23	0.0061421	0.0390160	0.8749099
Simple mode	23	-0.0663973	0.0892703	0.4648808
Weighted mode	23	-0.0065290	0.0618653	0.9169064

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.44340	21	0.6207978
Inverse variance weighted	18.59551	22	0.6701547

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022006	0.0056424	0.700454

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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