Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1253)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0208313	0.0998191	0.8367007
Weighted median	23	-0.0019081	0.0561157	0.9728742
Inverse variance weighted	23	-0.0334259	0.0390154	0.3915906
Simple mode	23	-0.0609228	0.1096018	0.5839190
Weighted mode	23	0.0559415	0.0959791	0.5659205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.29681	21	0.6929646
Inverse variance weighted	17.64554	22	0.7267854

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003332	0.0056423	0.5611359

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000557	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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