Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1252)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0933281	0.0998209	0.3604385
Weighted median	23	-0.0113485	0.0548408	0.8360606
Inverse variance weighted	23	0.0134184	0.0390156	0.7309028
Simple mode	23	-0.0643564	0.1008741	0.5300671
Weighted mode	23	-0.0408850	0.0634747	0.5261600

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.44952	21	0.6204072
Inverse variance weighted	19.79929	22	0.5955928

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065553	0.0056424	0.2583517

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006036	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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