Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1251)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0780310	0.0998211	0.4431106
Weighted median	23	-0.0084196	0.0552868	0.8789587
Inverse variance weighted	23	-0.0574404	0.0390157	0.1409560
Simple mode	23	-0.0190164	0.0991881	0.8497194
Weighted mode	23	0.0098853	0.0657618	0.8818818

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.19911	21	0.9340859
Inverse variance weighted	14.37306	22	0.8877117

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0083193	0.0056424	0.1552002

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005012	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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