Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1250)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0120817	0.1155471	0.9177166
Weighted median	23	-0.0420819	0.0558560	0.4512099
Inverse variance weighted	23	-0.0072396	0.0441587	0.8697745
Simple mode	23	0.0503335	0.0981662	0.6132445
Weighted mode	23	-0.0572856	0.0630153	0.3731628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.13834	21	0.1362713
Inverse variance weighted	28.18256	22	0.1697097

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011865	0.0065313	0.8575862

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008551	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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