Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 125)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0395249	0.0998202	0.6961282
Weighted median	23	0.0427154	0.0510583	0.4028173
Inverse variance weighted	23	-0.0020997	0.0390157	0.9570819
Simple mode	23	0.0459287	0.0859760	0.5985577
Weighted mode	23	0.0535850	0.0650235	0.4187352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.38918	21	0.6872617
Inverse variance weighted	17.59442	22	0.7297458

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025562	0.0056423	0.6551704

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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