Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1249)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0135730	0.0998209	0.8931369
Weighted median	23	-0.0353596	0.0530033	0.5046959
Inverse variance weighted	23	-0.0090871	0.0390157	0.8158331
Simple mode	23	-0.0315971	0.0903456	0.7298625
Weighted mode	23	-0.0422918	0.0585725	0.4778743

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.20574	21	0.5082651
Inverse variance weighted	20.20812	22	0.5700230

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002755	0.0056424	0.9615208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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