Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1248)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0142435	0.0998201	0.8878938
Weighted median	23	-0.0459518	0.0544534	0.3987400
Inverse variance weighted	23	-0.0235088	0.0390157	0.5468097
Simple mode	23	-0.0338385	0.0940142	0.7223316
Weighted mode	23	-0.0624038	0.0623017	0.3274084

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.61032	21	0.8419851
Inverse variance weighted	14.62049	22	0.8780035

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000569	0.0056423	0.9206324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004541	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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