Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1247)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0930838	0.0998205	0.3616704
Weighted median	23	0.0212367	0.0559700	0.7043683
Inverse variance weighted	23	0.0439990	0.0390156	0.2594350
Simple mode	23	0.0231685	0.0929508	0.8054757
Weighted mode	23	0.0283547	0.0637302	0.6607262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.31105	21	0.8558713
Inverse variance weighted	14.59645	22	0.8789669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030143	0.0056423	0.5987947

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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