Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1246)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0248342	0.1009680	0.8081006
Weighted median	23	-0.0211221	0.0578834	0.7151804
Inverse variance weighted	23	-0.0202420	0.0390154	0.6038857
Simple mode	23	0.0227967	0.1013326	0.8240802
Weighted mode	23	-0.0168582	0.0777735	0.8303926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.48579	21	0.4296412
Inverse variance weighted	21.48829	22	0.4907620

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000282	0.0057072	0.9610578

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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