Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1245)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0527996	0.1225472	0.6709668
Weighted median	23	0.0027141	0.0576103	0.9624240
Inverse variance weighted	23	0.0622559	0.0479422	0.1940942
Simple mode	23	0.0076348	0.1006417	0.9402152
Weighted mode	23	0.0152774	0.0574565	0.7927958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.65112	21	0.0634835
Inverse variance weighted	33.21922	22	0.0588560

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070655	0.0069269	0.3193335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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