Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1244)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1904956	0.0998205	0.0701061
Weighted median	23	-0.0630932	0.0566053	0.2650147
Inverse variance weighted	23	-0.0274224	0.0390156	0.4821437
Simple mode	23	-0.0037133	0.0881483	0.9667788
Weighted mode	23	-0.0807762	0.0647148	0.2250841

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.29092	21	0.8567816
Inverse variance weighted	17.44102	22	0.7385683

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100144	0.0056424	0.0904207

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005435	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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