Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1243)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1038645	0.0998208	0.3099353
Weighted median	23	0.0566814	0.0589708	0.3364638
Inverse variance weighted	23	0.0463618	0.0390158	0.2347213
Simple mode	23	0.0695080	0.0887609	0.4419219
Weighted mode	23	0.0715218	0.0700957	0.3186549

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	8.714970	21	0.9912847
Inverse variance weighted	9.106651	22	0.9927571

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035312	0.0056424	0.5381604

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003188	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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