Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1242)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0748649	0.1047999	0.4828703
Weighted median	23	-0.0530175	0.0552796	0.3375194
Inverse variance weighted	23	-0.0288361	0.0402362	0.4735784
Simple mode	23	0.0041935	0.0921041	0.9640957
Weighted mode	23	-0.0463641	0.0643078	0.4785188

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.14722	21	0.3361794
Inverse variance weighted	23.39819	22	0.3795454

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028266	0.0059238	0.6381737

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007256	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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