Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1241)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1102356	0.1206214	0.3711451
Weighted median	23	-0.1424273	0.0552187	0.0098992
Inverse variance weighted	23	-0.0693676	0.0462106	0.1333249
Simple mode	23	-0.1414912	0.0884654	0.1239965
Weighted mode	23	-0.1524841	0.0581681	0.0155864

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.66558	21	0.0794065
Inverse variance weighted	30.86344	22	0.0989440

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025097	0.0068182	0.7164875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001031	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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