Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1240)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1121355	0.1231374	0.3728127
Weighted median	23	0.0115307	0.0589083	0.8448143
Inverse variance weighted	23	0.0415839	0.0490383	0.3964444
Simple mode	23	-0.0322300	0.0925712	0.7310261
Weighted mode	23	-0.0068746	0.0662783	0.9183290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.95669	21	0.0591439
Inverse variance weighted	34.75578	22	0.0410817

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094398	0.0069603	0.1894261

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010874	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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