Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 124)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1200297	0.1110642	0.2920757
Weighted median	23	-0.0371276	0.0596931	0.5339581
Inverse variance weighted	23	-0.0587560	0.0427734	0.1695474
Simple mode	23	-0.0489551	0.0897357	0.5908660
Weighted mode	23	-0.0410897	0.0691727	0.5585610

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.99768	21	0.2065376
Inverse variance weighted	26.44242	22	0.2331720

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037628	0.0062779	0.5553347

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00087	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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