Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1239)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1288794	0.0998205	0.2106974
Weighted median	23	0.0286479	0.0529287	0.5883322
Inverse variance weighted	23	0.0003164	0.0390156	0.9935301
Simple mode	23	-0.0731116	0.1087921	0.5085614
Weighted mode	23	0.0958800	0.0668342	0.1654662

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	8.537539	21	0.9924097
Inverse variance weighted	10.495442	22	0.9812291

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078951	0.0056424	0.1763357

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003181	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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