Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1238)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0316640	0.1166425	0.7886868
Weighted median	23	-0.0089160	0.0557859	0.8730184
Inverse variance weighted	23	0.0265056	0.0445448	0.5518224
Simple mode	23	-0.0517804	0.0969508	0.5986360
Weighted mode	23	-0.0346791	0.0710037	0.6300902

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.67438	21	0.1220410
Inverse variance weighted	28.67753	22	0.1542998

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003168	0.0065932	0.9621335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000883	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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