Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1237)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1448769	0.1129614	0.2136320
Weighted median	23	-0.1094820	0.0571252	0.0552982
Inverse variance weighted	23	-0.0578757	0.0438501	0.1868841
Simple mode	23	-0.1138026	0.1060194	0.2947193
Weighted mode	23	-0.1276802	0.0642791	0.0595929

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.89400	21	0.1743895
Inverse variance weighted	27.79065	22	0.1827233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053427	0.0063851	0.4121551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009088	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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