Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1236)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0281793	0.0998208	0.7804779
Weighted median	23	0.0081111	0.0579311	0.8886499
Inverse variance weighted	23	0.0170840	0.0390155	0.6614753
Simple mode	23	0.1360546	0.0930128	0.1576759
Weighted mode	23	0.0223723	0.0650727	0.7342569

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.89331	21	0.4654760
Inverse variance weighted	20.90790	22	0.5264365

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006814	0.0056423	0.9050303

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006393	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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