Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1235)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0856659	0.0998199	0.4004689
Weighted median	23	0.0360385	0.0556227	0.5170436
Inverse variance weighted	23	0.0269951	0.0390155	0.4889967
Simple mode	23	-0.0010811	0.0892751	0.9904471
Weighted mode	23	0.1149790	0.0642018	0.0870800

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.45733	21	0.6199081
Inverse variance weighted	18.86509	22	0.6536437

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003603	0.0056423	0.5300095

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005862	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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